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Medicine

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Kidney

Question
9 out of 17
 

Bence Jones protein mostly derived from which chains? (AIPG 2010)



A ALFA
B Gamma

C MEU
D Delta

Ans. B Gamma

Bence Jones protein

A. A Bence Jones protein is a monoclonal globulin protein found in the blood or urine.

B. Found in multiple myeloma.

C. The proteins are immunoglobulin light chains (paraproteins) and are produced by neoplastic plasma cells. They can be kappa (most of the time) or lambda.

D. The light chains can be detected by heating or electrophoresis of concentrated urine. Light chains precipitate when heated to 50 - 60 degrees C and redisolve at 90 -100 degrees C.

E. Bence Jones proteins don't react with the reagents normally utilized in urinalysis dipsticks.

Kidney Flashcard List

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