Medical and Surgical Complications in Pregnancy
Biochemical marker of choice from cholestatic jaundice of pregnancy? AIPG 2011
Biochemical marker of choice from cholestatic jaundice of pregnancy is Bile salts
Cholestasis of pregnancy
1. Cholestasis of pregnancy occurs in the second and third trimesters and resolves after delivery.
2. Its cause is unknown, but the condition is probably inherited and cholestasis can be triggered by estrogen administration.
3. In cases of intrahepatic cholestasis of pregnancy, bile acids are cleared incompletely and accumulate in the dermis, which causes intense itching.
4. These patients develop pruritus in late pregnancy; there are no characteristic skin changes or rashes except in women who develop excoriations from scratching.
5. Cholestyramine is often used in cases of cholestasis of pregnancy to lower serum bile salts and decrease pruritus. 16 weeks.
6. In some cases, there can be a transient hepatic dysfunction. Intrahepatic cholestasis of pregnancy is characterized by pruritus and/or icterus. Some women develop cholestasis in the third trimester secondary to estrogen-induced changes.
7. There is an accumulation of serum bile salts, which causes the pruritus. Liver enzymes are seldom elevated above 250 U/L.