Biological role of metallothionein is to sequester harmful metal ions. These bind:
|A||CD++, Cu++& Zn++|
|B||A1+++, Hg++& NH4+|
|C||Pt+++, As+++& PO4|
|D||Fe+++, Na+& K+|
a. Metallothionein are a group of small proteins (about 6.5 kDa), found in the cytosol of cells, particularly of liver, kidney and intestine
b. They have a high content of cysteine and can binds copper (Cu), Zinc (Zn), Cadmium (Cd) and Mercury (Hg).
c. These proteins may function to store the above metals in a nontoxic form and are involved in their
overall metabolism in the body.