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Medicine

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Hematology

Question
1 out of 10
 

Blood components products are: (PGI Nov 2011)



A Whole blood
B Platelets

C Fresh frozen plasma
D Leukocyte depleted RBC

E All of the above

Ans. B

Platelets C. Fresh frozen plasma D. Leukocyte depleted RBC

Extra Edge: Fresh-Frozen Plasma

1. FFP contains stable coagulation factors and plasma proteins: fibrinogen, antithrombin, albumin, as well as proteins C and S.

2. Indications for FFP include correction of coagulopathies, including the rapid reversal of warfarin; supplying deficient plasma proteins; and treatment of thrombotic thrombocytopenic purpura.

3. FFP should not be routinely used to expand blood volume.

4. FFP is an acellular component and does not transmit intracellular infections, e.g., CMV.

5. Patients who are IgA-deficient and require plasma support should receive FFP from IgA-deficient donors to prevent anaphylaxis.

6. Extra Edge: Plasma Derivatives

7. Plasma from thousands of donors may be pooled to derive specific protein concentrates, including albumin, intravenous immunoglobulin, antithrombin, and coagulation factors.

8. In addition, donors who have high-titer antibodies to specific agents or antigens provide hyperimmune globulins, such as anti-D (RhoGam, WinRho), and antisera to hepatitis B virus (HBV), varicella-zoster virus, CMV, and other infectious agents.

Extra Edge: (Ref. Hari-18th ed. Pg. 886)

Blood substitute: Two main compounds have been pursued:

1. fluorocarbon synthetic chemicals that bind oxygen reversibly, and

2. artificially modified hemoglobins, known as hemoglobin-based oxygen carriers (HBOC).

Hematology Flashcard List

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