Blood glucose levels cannot be augmented by mobilization of muscle glycogen due to lack of
|A||G —6— P dehydrogenase|
|B||G — 6 — phosphatase|
Glycogenolysis →Breaks down of glycogen into glucose. Glycogen is ( 1→4 and 1 →6 glycosyl units)x
a. First step — by Phosphorylase rate limiting step in glycogenolysis →specific for phosphorylysis break downing (phosphorolysis) of the 1→4 linkage of glycogen to yield — glucose — 1- phosphate
Break until 4; glucose residue remains on either side of 1→ 6 branch.
b. 2nd Enzyme → Glucan transferase →transfers trisaccharides (3-glucose) → exposing l→6 branch point
c. 3rd enzyme → enzyme (Amylo [ →6] glucosidase)
d. Release G-1-P is converted into G-6-P by phosphoglucomutase
e. Final step is G-6-P — acted upon by Glu-6-phosphatase enzyme — to release glucose into the blood →glucose.
a. Normally G-6-phosphatase presents in Liver and kidney but not in muscles.
b. Deficiency of glu-6-phosphatase — causes von-Gierke disease (Typel) → in which Hypoglycemia occurs.