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4 out of 6

CD 19 positive, CD22 positive, CD 103 positive monoclonal B-cells with bright kappa positivity were

found to comprise 60% of the peripheral blood lymphoid cells on flow cytometric analysis in a 55 year old man with massive splenomegaly and a total leucocyte count of 3.3 x 109/L. Which one of the following is the most likely diagnosis? (AIIMS Nov 2012)

A Splenic lymphoma with villous lymphocytes

B Mantle cell lymphoma

C B-cell pro lymphocytic leukemia

D Hairy cell leukemia

Ans. D Hairy cell leukemia