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Anti-Anxiety Drugs

 

Anxiety

  • It is an emotional state, unpleasant in nature, associated with uneasiness; discomfort and concern or fear about some defined or undefined future threat. Some degree of anxiety is a part of normal life.
  • Treatment is needed when it is disproportionate to the situation and excessive.

Cause:

  • Increase in serotonergic and reduction in GABAergic activity in brain.

Drugs:

Benzodiazepines

Azapirones

Antihistaminics

Beta-Blockers

Alprazolam

Clonazepam

Diazepam

Oxazepam

Lorazepam

Chlordiazepoxide

Buspirone

Gepirone

Ispapirone

 

Hydroxyzine

Propanolol

1) Oxazepam, Lorazepam: useful in elderly with hepatic disease

2) Chlordiazepoxide is for chronic anxiety

3) S/E: Cognitive impairment, sedation, abuse potential

 

1) Partial Agonist at 5-HT1A auto-receptors there by decreasing serotonin release

2) Take up to 2 weeks to act, hence useless in acute anxiety states

3) ADV: No adverse of BZD”s.

1) Centrally acting first generation antihistaminics

2) Causes profound Sedation

1) Used in performance Anxiety

 

 

 





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