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Epipodophyllotoxin

  1. Etoposide
  2. Teniposide
  3. Inhibit TOPOISOMERASE II
  4. Used in leukemia/lymphoma
  5. Also in testicular/ovarian Ca

Enzyme

  1. L-asarginase
  2. Bacterial product
  3. Given as IV infusion
  4. Use
    1. Induction of ALL
    2. S/E
      1. Hypersensitivity               
      2. Pancreatitis      
      3. Hypercoagulable syndrome (Inhibits Antithrombin III)





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