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Newer Drugs

 

 

DRUG (Mechanism of action)       

USE/S

Bevacizumab (anti – VEGF antibody

Metastatic carcinoma of the colon of rectum

Pemetrexed (folate enzyme antagonist)

Malignant pleural mestothelioma

Erlotinib (tyrosine kinase inhibitor)

Non- Small – cell lung cancer

Gefitib (tyrosine kinase inhibitor)

Non – small cell lung cancer

Imatinib mesylate

(Anti- tyrosome kinase)

leukemia (CML (DOC)

Chronic myeloid Inoperable and/or metastatic malignant gastrointestinal stomal tumors (GISTs)

Bortezomib (proteosome inhibitor)

Multiple myeloma

Amifostine (SH donating agent)

Cancer chemotherapy (DOC for reducting toxicities)

Cepecitabine (Pyrimidine analogue)

Antimetabolite

Natalizumab (monoclonal antibody)

Multiple myeloma/severe Chrohn’s syndrome (alpha-4 integrin inhibitor)

Pegaptanib (VEGF antagonist)

Age related macular degeneration

Gemtuzumab (Anti-CD33)

Acute leulemia

Alemtuzumab (Anti-CD52)

Chronic leukemia

Lapatibib (Tyrosine kinase inhibitor)

Solid tumors

Temozolamide (Alkylating agent)

Brain tumor (Glioblastoma multiforme)

Trustuzumanb (HER2 antagonist)

Breast cancer

Efoproxiral (Hb Utilization enhancer)

Brain cancers

Cloretazine (Alkylating agent)

Refractory leukemias

Glufosphamide (Alkylating agent)

Pancreatic cancer

Tirapazamine (Tissue sensitizer)

Solid cancer

Cituximab (EGF antagonist)

Colorectal cancer

Rituximab (Anti-CD20)

NHL, rheumatoid arthritis

Daclizumab (IL-2 antagonist)

Organ transplant rejection

Basiliximab (IL-2 antagonist)

Organ transplant rejection

Dasatinib (Tyrosine kinase inhibitor)

Chronic leukemias

Sorafenib (Tyrosine kinase inhibitor)

Advanced liver cancer

Canakinumab (human anti-human-IL-1beta(ß) monoclonal antibody)

Cryopyrin-Associated Periodic Syndromes (CAPS)

Everolimus (CNI)

RCC/cardiac transplant

Plerixafor (Stem cell stimulator; inhibitor of CXCR4 chemokine receptor.)

Non-Hodgkin’s lymphoma

Eculizumab (Anti-complement protein 5)

paroxysmal nocturnal hemoglobinuria

Temsirolimus

RCC

Xabepilone (Microtubule stabliser)

Breast cancer

Nilotinib (New TK inhibitor)

CML

Lepatinib (EGF/HER blocker)

Breast cancer

Decitabine/azacitidine (Hypomethylating agents)

Myelodysplastic syndromes

Sunitinib (multiple-targeted tyrosine kinase inhibitor)

GI tumors

Ranibizumab (recombinant humanized IgG1 kappa isotype)

Age related macular degeneration

Sipuleucel (anti prostatic acid phosphates)

Prostatic cancer





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