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Pharmacology

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Blood

Question
11 out of 45
 

Carbonic anhydrase does not act if given with high dose of EDTA. (LQ)



A EDTA forms a complex with substrate

B EDTA combines with the metal ion of enzyme

C It combines with the substrate and forms a suicide inhibitor

D Combines with the substrate and doesn't react with the enzyme

Ans. B EDTA combines with the metal ion of enzyme

a. EDTA is a chelating agent and it can chelate various divalent and trivalent ions like Pb, Zn, Ca, Cu, Mn, Fe and

various radionuclide agents.

b. EDTA is a polar compound, so do not get absorbed by oral as it is unable to cross cell membrane, therefore it

is given by i.v. route.

c. As it is lipid insoluble, it chelates mostly those ions which are present in extracellular spaces like Pb, Ca ,Zn

d. By this action it is preferred agent for lead toxicity (nowadays succimer is agent of choice for lead poisoning).

e. By its action it can cause hypocalcemia and can interfere with those enzyme having zinc and copper in their structure.

f. Therefore, nowadays it has been standardized to use di calcium or zinc salts of EDTA for clinical use.

g. Carbonic anhydrase is an enzyme having zinc ion in its structure.

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