Loading....
Coupon Accepted Successfully!

 

Miscellaneous drugs

  1. Adenosine
    1. Very potent                                     
    2. Shortest acting        
    3. Half life =10 seconds (Given as IV infusion)              
    4. Acts upon A1 & A2 receptors
       
      Both are G protein coupled receptors; increase K+ permeability
    5. A1 is therapeutic &  A2 contribute to side effects. 
    6. Adenosine is AV nodal blocker
    7. DOC for PSVT
    8. Side effects are:
      1. Flushing
      2. AV Block (Heart Block)
    9. Drug interactions
  • Theophylline blunts its effects
    • It is adenosine blocker
  • Dipyridamol potentiates
    • It is adenosine reuptake inhibitor
  1. Amrinone/milrinone (bipyridines)
    1. Short acting
    2. Proarrhythmics
    3. PD-III inhibitors-increase cAMP
    4. K/a inodilators-increase contractility & dilate blood vessels
    5. Use
  • CHF with arrhythmias (DOC is amiodarone)

S/E

Thrombocytopenia (Amrinone causes more, milrinone causes less)

  1. Magnesium
    1. Suppresses early after depolarization
    2. Used in torsa de depointes (IV)
  2. Digoxin
    AV blocker; used in PSVT to prevent recurrence

 





Test Your Skills Now!
Take a Quiz now
Reviewer Name