7 out of 91
Carisoprodol activation forms which metabolite: (LQ)
Ans. B Meprobamate
- Carisiprodol is a rapidly acting and is a centrally acting muscle relaxant.
- The drug blocks the electrical communication among the central nerves in brain.
- The drug starts acting with in 20 minutes and the effects last for 2-6 hours.
- It is metabolized quickly by cytochromal enzymes to maprobamate, which is an independent muscle relaxant.
- However, maprobamate has abuse potential. Usual dose of carisiprodol is 350 mg daily and sedation is main side effect.
- Carisiprodol is believed to have less abuse potential.
- Maprobamate was used in the past as a selective anti-anxiety drug with insomnia.
- However, now a days, benzodiazepines are the drugs of choice for this condition.
- Presently, though, carisiprodol type of drugs are used orally sometimes in orthopaedic conditions; they are often given in combination with NSAIDs as topical formulations for back pain, sprains, lumbago etc.