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Medicine

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Hematology

Question
8 out of 16
 

Cause of ITP is: (AIPG 2010)



A Vasculitis

B Antibody to vascular epithelium

C Antibody to platelets

D Antibody to clotting factors

Ans. C

Antibody to platelets

Quantitative Platelet Disorders

Thrombocytopenia: Spontaneous bleeding occurs when the platelet count falls below 20,000 - 30000/ml

Causes

1. Decreased production of platelet

a. Hypoplasia of the marrow (idiopathic, or drug induced)

b. Megaloblastoses (B12 or folate deficiency)

c. Infiltration of the bone marrow (leukemia, myeloma, carcinoma)

2. Decreased platelet survival:

a. ITP b. HIV c. DIC d. Drugs (quinine, quinidine, methyldopa)

e. SLE f. Lymphoma g. TTP

3. Platelet sequestration (hypersplenism)

4. Defective platelet aggregation (aspirin, heparin)

5. Dilutional (massive blood transfusion)

Extra Edge: (Ref. Hari 18th ed., Pg. 972)

Heyde's syndrome (aortic stenosis with gastrointestinal bleeding) is attributed to the presence of angiodysplasia of the gastrointestinal tract in patients with aortic stenosis. However, the shear stress on blood passing through the stenotic aortic valve appears to produce a change in VWF, making it susceptible to serum proteases.

Immune Thrombocytopenic Purpura (ITP) (Ref. Hari-18th ed., Pg.- 969)

It is an autoimmune disorder due to the presence of auto- antibodies directed against platelet membrane glycoprotein IIb and IIIa resulting in premature removal of platelet by macrophage monocyte system.

Hematology Flashcard List

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