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Medicine

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Respiratory

Question
5 out of 10
 

Cause of nephrocalcinosis in Chronic granulomatous disease? (AIIMS Nov 2010)


A Increased calcium absorption

B Increased extrarenal conversion of 25 (OH) cholecalciferol to 1, 25 (OH)2 cholecalciferol vitamin D.
C Dystrophic calcification

D Mutation in calcium sensing receptor

Ans. B

Increased extrarenal conversion to 1,25 OH vitamin D

Calcium Metabolism in Sarcoidosis (Ref: Harrison, 18th edition, Page 2809) (AIIMS Nov 2010)

1). Hypercalcemia and/or hypercalciuria occurs in about 10% of sarcoidosis patients.

2). The mechanism of abnormal calcium metabolism is increased production of 1, 25-dihydroxyvitamin D by the granuloma itself.

3). The 1,25-dihydroxyvitamin D causes increased intestinal absorption of calcium, leading to hypercalcemia with a suppressed parathyroid hormone (PTH) level.

Tests Blood:

1). ESR Increased 2). Lymphopenia

3). Raised serum ACE 4). Raised serum Ca2+

5). Raised immunoglobulins 6). Raised 24h urine Ca2+.

Respiratory Flashcard List

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