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Physiology

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Respiration

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Cause of sigmoid shape of O2 curve? (AIPG 2009 )



A Binding of one O2 molecule increase the affinity of binding of other O2 molecules.

B Binding of one O2 molecule decrease the affinity of binding of other O2 molecules.

C Bohr effect

D Haldane effect

Ans. A Binding of one O2 molecule increase the affinity of binding of other O2 molecules. This is also called relative affinity

I. Hemoglobin contains four globin chains and the oxygenation of each chain causes structural changes that increase the affinity of the haem of the remaining chains for oxygen.

II. This increases oxygen affinity, as oxygen loads is the cause of the sigmoid shape of the dissociation curve. Initially the slope is flat as affinity is low then due to “relative affinity” the slope increases and then as the Hb gets saturated the slope again becomes flat (plateau phase).

Oxygen-hemoglobin dissociation curve

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