16 out of 42
Cell type, which lacks HLA antigen, is: (DNB Dec. – 2008)
|D||Red blood cell|
Ans. D Red blood cell
- Antigen presenting cells include specialized cells called dendritic cells in the lymph nodes and spleen and the Langerhans dendritic cells in the skin Macrophages and B cells themselves can also function as antigen presenting cells.
- In antigen-presenting cells, polypeptide products of antigen digestion are coupled to protein products of the major histocompatibility (H LA) complex genes and presented on the surface of the cells.
- The products of the MHC genes are called human leukocyte antigens (HLA) The genes of the HLA are located on the short arm of chromosome 6 Q, encode glycoproteins and are divided in two classes based on their distribution and function.
- The class I antigens are found on all ‘nucleated’ cells while the class II antigens are present in antigen-presenting cells including B cells and activated T cells. Q