Loading....
Coupon Accepted Successfully!

Pharmacology

Open Flashcards

Antibiotics Part-1

Question
71 out of 86
 

Cell wall synthesis is inhibited by?



A Erythromycin
B Lomefloxacin

C Cefipime
D Tetracycline

Ans. C Cefipime (Ref. Harrison’s medicine 16th eD. 790)

MECHANISM/ SITE OF ACTION OF VARIOUS ANTIBIOTICS:

CELL WALL

INHIBITION

PROTEIN

SYNTHESIS

INHIBITION

CELL METABOLISM

INHIBITION

ACTING ON

CELL MEMBRANE

DNA SYNTHESIS

INHIBITION

INHIBITION OF

NUCLEIC ACID

SYNTHESIS

Beta-lactums

(Penicillins, Cephalosporins, Carbapenems, Monobactums)

Macrolides

Sulphonamides

Polymyxin B

Quinolones

Rifampicin

Vancomycin

Lincosamides

Trimethoprim

Gramicidin

Novobiocin

Metronidazole

Bacitracin

Chloramphenicol

Nitrofurantoin

Tetracyclins

Aminoglycosides

Mupirocin

Quinupristin

Dalfopristin

Linezolid

a. Aminoglycosides:Inhibit protein synthesis by binding to a portion of the bacterial ribosome. Most of them are bacteriocidal (i.e., cause bacterial cell death).

b. Bacitracin:Inhibits cell wall production by blocking the step in the process (recycling of the membrane lipid carrier) which is needed to add on new cell wall subunits.

c. Beta-lactam antibiotics:A name for the group of antibiotics which contain a specific chemical structure (i.e., a beta-lactam ring). This includes penicillins, cephalosporins, carbapenems and monobactams.

d. Cephalosporins:Similar to penicillins in their mode of action but they treat a broader range of bacterial infections. They have structural similarities to penicillins and many people with allergies to penicillins also have allergic reactions to cephalosporins.

e. Chloramphenicol:Inhibits protein synthesis by binding to a subunit of bacterial ribosomes (50S).

f. Glycopeptides(e.g., vancomycin): Interferes with cell wall development by blocking the attachment of new cell wall subunits (muramyl pentapeptides).

g. Macrolides(e.g., erythromycin) and Lincosamides (e.g., clindamycin): Inhibit protein synthesis by binding to a subunit of the bacterial ribosome (50S).

h. Penicillins:Inhibits formation of the bacterial cell wall by blocking cross-linking of the cell wall structure. The cell wall is a needed protective casing for the bacterial cell.

i. Quinolones:Blocks DNA synthesis by inhibiting one of the enzymes (DNA gyrase) needed in this process.

j. Rifampin:Inhibits RNA synthesis by inhibiting one of the enzymes (DNA-dependent RNA polymerase) needed in this process. RNA is needed to make proteins.

k. Tetracyclines:Inhibit protein synthesis by binding to the subunit of the bacterial ribosome (30S subunit).

l. Trimethoprim and Sulfonamides:Blocks cell metabolism by inhibiting enzymes which are needed in the biosynthesis of folic acid which is a necessary cell compounD.

Antibiotics Part-1 Flashcard List

86 flashcards
1)
2)
3)
4)
5)
6)
7)
8)
9)
10)
11)
12)
13)
14)
15)
16)
17)
18)
19)
20)
21)
22)
23)
24)
25)
26)
27)
28)
29)
30)
31)
32)
33)
34)
35)
36)
37)
38)
39)
40)
41)
42)
43)
44)
45)
46)
47)
48)
49)
50)
51)
52)
53)
54)
55)
56)
57)
58)
59)
60)
61)
62)
63)
64)
65)
66)
67)
68)
69)
70)
71)
72)
73)
74)
75)
76)
77)
78)
79)
80)
81)
82)
83)
84)
85)
86)