Cerebellar ataxia is caused by (LQ)
a. Cytarabine is used intrathecally for meningeal leukemia. This can cause cerebellar toxicity – ataxia & slurred speech as well as cerebral toxicity – seizures, dementia, coma etc. Coma may follow esp. in old age patients as well in those with reduced renal function. The other side effects are potent myelosuppression, GIT & mucosal side effects, dermatitis, reversible rise in LFT & pulmonary side effects.
b. Cisplatin causes peripheral neuropathy.
c. Major toxicity with busulfan is myelosuppression while with high dose it can cause veno-occlusive disease of liver, seizures, hemorrhagic cystitis, cataracts and alopecia.
d. Bleomycin causes little myelosuppression; but high cutaneous & pulmonary toxicity. It does not exhibit neurotoxicity.