Liver & GIT
Chance of vertical transmission in Hepatitis B is? (LQ)
Hepatitis B may be spread from infected mothers to their babies at birth ('vertical' transmission).
1. The rate of transmission of hepatitis B from mother to newborn is very high, and almost all infected infants will develop chronic hepatitis B.
2. Transmission can be significantly reduced through immunoprophylaxis.
3. This risk is as high as 90% if the mother is also positive for HBeAg.
4. Symptoms usually begin 6 weeks to 6 months after exposure to the virus (average 2 months). Hepatitis has age dependent prognosis.
5. Children are less likely than adults to clear the infection. More than 95% of people who become infected as adults or older children will stage a full recovery and develop protective immunity to the virus.
6. However, this drops to 30% for younger children, and only 5% of newborns that acquire the infection from their mother at birth will clear the infection.
Window period = Disappearance of HBs antigen & appearance of HBs Ab
Sexual B >>> C (Rare) (Ref. Hari- 18th ed., Pg. 2546)
Vertical B >>> C (uncommon)
Chronicity C >>> B
Tattooing B = C