30 out of 95
Chediak-Higashi syndrome is associated with detect in: (DNB Dec. 2009)
Ans. A Chemotaxis
- Chediak-Higashi syndrome is a rare disease with autosomal recessive Q inheritance.
- Neutrophils and all cells containing lysosomes from patients with Chediak-Higashi syndrome characteristically have large granules.
- Chediak-Higashi syndrome neutrophils and monocytes have impaired chemotaxis and abnormal rates of microbial killing slow rates of fusion of the lysosomal granules with phagosomes.
- Natural killer cell function is also impaired