Chemotaxis in response to activation of cells results in- (AIPG 2012)
|A||Random multidirectional movement|
|C||Adhesion to endothelium|
|D||Augmented oxygen dependent bactericidal effect|
· After extravasation from the blood vessels, leukocytes emigrate in tissues towards the site of injury by chemotaxis.
· Chemotaxis is unidirectional locomotion oriented along a chemical gradient
· This chemical gradient is created by the substance called chemoattractants (chemotactic agents), which may be:-
1. Exogenous → Bacterial products
2. Endogenous → C5a, LTB4, IL-1, TNF, IL-8
Note: C5a is the most powerful chemoattractant.