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Pharmacology

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General Pharmacology

Question
66 out of 91
 

Child with phocomelia anomaly due to drug taken by mother (AIIMS Nov 2010)


A Tetracycline
B Thalidomide

C Steroids
D lithium

Ans. B Thalidomide

Thalidomide syndrome symptoms

· When an individual is born with phocomelia due to drugs or pharmaceuticals, it is known as thalidomide syndrome.

· The symptoms of thalidomide syndrome are defined by absent or shortened limbs; causing flipper hands and feet.

They can have additionally following feature:

  1. Palsy disorder of the face
  2. Ear and eye abnormalities; resulting in limited/complete loss of hearing or sight
  3. Gastrointestinal and genitourinary tract disorders
  4. Ingrown genitalia
  5. Undeveloped/missing lungs
  6. Distorted digestive tract, heart, kidney

History Of Thalidomide Syndrome

a. Thalidomide was released into the market in 1957 in West Germany under the label of Contergan.

b. Primarily prescribed as a sedative or hypnotic, thalidomide also claimed to cure “anxiety, insomnia, gastritis, and tension.”

c. Afterwards it was used to combat against nausea and alleviate morning sickness in pregnant women.

d. Thalidomide became an over the counter drug in Germany around 1960, and could be purchased without a prescription.

e. Shortly after the drug’s selling, in Germany, between 5,000 and 7,000 infants were born with the qualities of phocomelia. Out of these children merely 40% of them survived

f. Cases of severe phocomelia amplified; the direct cause was linked to thalidomide.

General Pharmacology Flashcard List

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