Clomiphene citrate, which is true: (LQ)
|A||Twin pregnancy in 5-6% of pregnancies|
|B||3 fold increase in pregnancy compare to placebo|
|C||Enclomiphene acts an antiestrogen|
|D||It can also be used for male infertility with oligozoospermia|
a. A partial estrogen agonist
b. In humans it leads to an increase in the secretion of gonadotrophins and estrogen by inhibiting Estradiol’s negative feedback effect on the gonadotrophins.
a. The orally bioavailable citrate salt of enclomiphene, the trans-isomer of the nonsteroidal triphenylethylene compound clomiphene, with tissue-selective estrogenic and antiestrogenic activities. As a selective estrogen receptor modulator (SERM), enclomiphene binds to hypothalamic estrogen receptors, blocking the negative feedback of endogenous estrogens and stimulating the release of gonadotropin – releasing hormone (GnRH) from the hypothalamus; released GnRH subsequently stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary, resulting in ovulation.
a. Hot flushes (most common)
b. Ovarian hyperstimulation
c. Headache, constipation, allergic skin reaction, reversible hair loss.
d. Multiple pregnancy: Incidence is about 10%.