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Medicine

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Kidney

Question
18 out of 20
 

Complement level is reduced in (AIIMS May 09)



A Minimal change

B Membranous

C Focal & segmental

D Membrane proliferative GN

Ans. D Membrane proliferative GN

Clinical Feature

i. They present with microscopic to gross hematuria and selective or non – selective proteinuria depending on the severity of the disease.

ii. They have a poor prognosis, developing renal failure 5 – 10 years after diagnosis.

iii. Complement level is reduced

Summary of logy of Primary Glomerular diseases.

1. Minimal change GN – Loss of foot process

2. Membranous (Heyman’s) GN – Sub epithelial deposition, spike and dome pattern.

3. FSGS – Loss of foot process, Mesangial deposition, detachment of basement membrane from epithelium.

4. MPGN – Mesangial cell proliferation, Splitting of BM (Tram track appearance)

Type I – Subendothelial deposition

Type II – Intramembranous deposition

5. Post streptococcal GN- Sub epithelial, Intramembranous and Sub endothelial deposition.

6. RPGN – Crescent formation by multiplying of parietal epithelial cells.

7. Good pasture – Intramembranous deposition of immunocomplex.

Extra Edge: Compliment levels are normal in a. Minimal change GN b. Membranous GN c. FSGS

Kidney Flashcard List

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