Complement level is reduced in (AIIMS May 09)
|C||Focal & segmental|
|D||Membrane proliferative GN|
i. They present with microscopic to gross hematuria and selective or non – selective proteinuria depending on the severity of the disease.
ii. They have a poor prognosis, developing renal failure 5 – 10 years after diagnosis.
iii. Complement level is reduced
Summary of logy of Primary Glomerular diseases.
1. Minimal change GN – Loss of foot process
2. Membranous (Heyman’s) GN – Sub epithelial deposition, spike and dome pattern.
3. FSGS – Loss of foot process, Mesangial deposition, detachment of basement membrane from epithelium.
4. MPGN – Mesangial cell proliferation, Splitting of BM (Tram track appearance)
Type I – Subendothelial deposition
Type II – Intramembranous deposition
5. Post streptococcal GN- Sub epithelial, Intramembranous and Sub endothelial deposition.
6. RPGN – Crescent formation by multiplying of parietal epithelial cells.
7. Good pasture – Intramembranous deposition of immunocomplex.
Extra Edge: Compliment levels are normal in a. Minimal change GN b. Membranous GN c. FSGS