Confirmatory investigation for Acromegaly is: (LQ)
|A||Insulin induced GH suppression|
|B||Glucose induced GH suppression|
|C||Random GH assay|
|D||IGF - I level|
Glucose induced GH suppression
1). Increase heal pad thickness seen on X-ray lateral view of the heal
Most common cause of increase heal pad thickness is heal injury (AIIMS Nov 2010).
2). Elevated IGF-I. Usually > 5 times normal.
3). Serum GH not suppressed following oral glucose. OGTT test (75 gms of glucose given. After 1 hour if GH>1 ng/ml- suggestive of GH tumor.) It is the most definite test.
4). Confirmation- MRI/CT neoplasm