Corneal transplantation (AIPG 2010)
|A||Donor > 60 yrs not allowed|
|B||Whole eye preserved in culture|
|C||Specular microscopy done for corneal endothelial count|
|D||HLA matching required|
Ref. Leibowitz Page 848
1. Option A:
a. Corneas from donors much younger than age 5 are thin, soft, and difficult to handle.
b. Corneas from donors much older than 60 years of age tend to have fewer endothelial cells than tissue from younger individuals. However, age is never a contraindieation
2. Option B
a. The scientific basis for 4oC storage – the only preservation method used during the first 40 years of eye banking.
b. Storage at 4oC.
c. Soon after death.
d. Cornea with a 2 to 3 mm scleral rim is removed from the globe and is the only part of the eye that is preserved.
a. The collaborative corneal transplantation studies were a set of two multicenter clinical trails designed to investigate the efficacy of donor recipient matching of human leukocyte antigens (HLA-A, HLA-B, and HLA-DR)
b. Matching for HLA-A, HLA-B, and HLA-DR antigens had no effect on overall graft survival, the incidence or irreversible rejection, or the incidence of rejection episodes.