Crescentic Glomerulonephritis may be seen in all of the following Except? (AI 2008)
|A||Post Streptococcal Glomerulonephritis (PSGN)|
|C||Anti Basement Membrane Disease|
RPGN is defined by 2 criteria.
i. Presence of epithelial crescents in more than 70% of glomeruli
ii. Occurrence of rapidly progressive renal failure, End stage disease occurs within month
1. Individuals typically present with rapid, progressive &irreversible deterioration of renal function.
2. It may be primary(idiopathic) or secondary.
Important Points: The prognosis of RPGN depends upon Number of crescents.
i. Crescents are produced by Proliferation of the parietal epithelial cells of Bowman 's capsule, Infiltration of monocytes and macrophages.
ii. RPGN is a syndrome associated with severe glomerular injury.
It does not denote a specific etiologic form of glomerulonephritis.
Causes of RPGN
1. Primary (idiopathic) diffuse crescentic glomerulonephritis
a. Type I: anti-GBM antibody disease without pulmonary hemorrhage
b. Membrane Proliferative glomerulonephritis (especially type II)
c. Membranous glomerulonephritis with or without superimposed anti-GBM antibody disease,
d. IgA nephropathy (Berger's disease)
2. In Association with Infectious Diseases
a. Poststreptococcal glomerulonephritis b. Infective endocarditis
c. Hepatitis B
3. In Association with Multisystem Diseases
c. Henoch-Schönleinpurpura-disseminated vasculitis
d. Wegener's granulomatosis
e. Microscopic polyarteritis (hypersensitivity angiitis)
4. Other variants
a. Cryoimmunoglobulinemia (mixed, essential)
b. Lung cancer, lymphoma