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Medicine

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Endocrine

Question
9 out of 10
 

Criteria for primary hyperaldosteronism are all except (AIIMS Nov 2011)



A Diastolic hypertension without edema

B Metabolic acidosis present

C Low secretion of renin

D Low secretion of aldosterone in spite of reduced volume of fluid

Ans. B

Metabolic acidosis present

Clinical features of Conn’s syndrome:

1).Weakness, cramps, paraesthesia,

2).Polyuria, polydipsia. Impaired concentrating ability of kidney causes polyuria, Polydipsia

3). Hypernatremia

4). Hypertension

5). Hypokalemia

6).Metabolic Alkalosis (AIIMS Nov 2011) (Ref. Hari 18th Pg. 342, 247)

7). Ventricular arrhythmia

8). Muscle wasting (Proximal myopathy),

Extra Edge: Oedema feet is not a feature of primary hyperaldosteronism & SIADH

Tests


1). Primary hyperaldosteronism

a. Aldosterone

b. Renin(AIIMS Nov 2011)

2). Secondary hyperaldosteronism

a. in Renin

b. Aldosterone


Extra Edge: In Addison disease Renin and Aldosterone

Treatment:

a. Conn’s : Adrenalectomy.

b. Hyperplasia: Treated medically: spironolactone, Eplerenone

2). Secondary hyperaldosteronism

a. Renal artery stenosis

b. Accelerated hypertension

c. CCF

d. Hepatic failure

e. Nephrotic syndrome

Treatment: Spironolactone, Eplerenone

Recent Advances:

Eplerenone: A new selective aldosterone receptor antagonist, which does not cause gynecomastia (PQ)

Endocrine Flashcard List

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