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Dermatology

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Genodermatoses

Question
10 out of 14
 

Crocodile skin or sauroderma is seen in:



A Toxic epidermal necrolysis
B Darier's syndrome

C Psoriasis
D Ichthyosis vulgaris

Ans. D
Ichthyosis vulgaris

Feature of different types of ichthyosis

Feature

Ichthyosis vulgaris

X-linked ichthyosis

Lamellar ichthyosis

Epidermolytic hyperkeratosis

Inheritance

Autosomal dominant

X-linked recessive

Autosomal recessive

Autosomal dominant

Severity

Mild

Moderate

Severe

Severe

Defect

Deficiency of filaggrin protein

Deficiency of steroid sulphate enzyme

Deficiency of epidermal transglutaminase

Abnormality of keratin

Distribution

All over body

Allover body

All over body, very severe involves flexures, neck face, scaly palms and soles

All over body, Bullae and hyperkeratotic lesions on knees, elbows, Palmoplantar keratoderma

Onset

Childhood/puberty

Infancy/childhood

Birth-collodion baby

Birth-bullae, erythroderma

Involved areas

Entire body, palms, soles

Involves flexures, neck, face

Involves flexures, neck face, scaly palms, soles

All over body

Spared areas

Flexures and face

Palms and soles spared

None

None

Other features

Very mild, improves in summer

Scales are brown- black

Seal es are large, quadrangular, adherent

Severely disabling

Treatment

Emollients

Emollients

Retinoids-acitretin

No satisfactory treatment

Prognosis

Good

Good

Causes serious disability

Causes serious disability

Genodermatoses Flashcard List

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