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Dermatology

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Leprosy

Question
4 out of 28
 

DOC for lepra II reaction is (LQ)



A Steroids
B Thalidomide

C Clofazimine
D Dapsone

Ans. B
Thalidomide

1). Treatment of ENL must be individualized.

2). If ENL is mild (i.e., other organ involvement, with occasional crops of 1 papules), it may be treated with antipyretics alone.

3). However in cases with many skin lesions, fever, malaise, and other tissue involvement brief courses (1–2 weeks) of glucocorticoids 60 mg/day) is often effective.

4). Successful therapy is defined by the cessation of skin lesion development and the disappearance of the systemic signs and symptoms.

5). The mechanism of thalidomide’s dramatic action against ENL is reduction of TNF levels and IgM synthesis and its slowing of polymorphonuclear leukocyte migration. (Dose – 100 – 400mg/day)

Leprosy Flashcard List

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