DOC in severe complicated falciparum malaria:
a. Quinine is the drug of choice for cerebral malaria. Artemisnins are used in severe malaria. Chloroquine resistance makes it useless in this indication.
b. Quinine is given in 5% or 10% Dextrose infusion. It should never be mixed in saline containing solution otherwise it gets precipitated. The main side effects of Quinine are vomiting, tinnitus, Hypotension.