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Medicine

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Hematology

Question
9 out of 21
 

Diagnosis of Hodgkin’s disease is based on all of the following, except: (PGI Nov 2011)



A Reed- Sternberg cells

B Reactive cellular background

C Atypical cells in background

D CD 30 positivity

Ans. C

Atypical cells in background

Hodgkin’s lymphoma

Immuno pheno type

Association with EBV

Read Sternberg cell variant

Nodular sclerosis

CD15 + , CD30+

CD20 ve , CD45 -ve

EBV - Ve

Lacunar cells (occasional R-S-cells)

Mixed cellularity

CD15 + , CD30+

CD20 ve , CD45 -ve

EBV + Ve (70%)

Classic reed Sternberg cells

Lymphocyte depletion

CD15 + , CD30+

CD20 ve , CD45 -ve

EBV + Ve

Reticular variant (Frequent R-S cells)

WORST prognosis

Lymphocyte predominance

CD15 -ve , CD30 –ve

CD20 +ve , CD45 +ve

EBV – Ve

Popcorn cell variant

BEST prognosis

Hematology Flashcard List

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