Digoxin action is influenced by all except
|B||Myocardial isc hemia|
A. Hypokalemia (electrolyte disturbance) enhances toxicity by increasing its binding to Na+ K+ ATPase
B. Myocardial ischemia: Arrhythmogenic does of Digoxin should be reduced after MI. It should be given only when there is associated Atrial fibrillation and ventricular tachycardia with heart failure.
C. Digoxin is primarily excreted unchanged by kidney by glomerular filtration. Rate of excretion is altered parallel to creatinine clearance.