Gram Positive Bacilli
Diphtheria is characterized by all except
|C||Most common clinical form being faucial|
|D||Causes striking edematous swelling of cervical region|
a. In diphtheria, organism most commonly multiplies in the upper respiratory tract (faucial being the most common variety). The organism produces a powerful exotoxin (diphtheria toxin), which is absorbed from the local site of multiplication causing toxaemia.
b. Local, toxin causes necrotic damage resulting in the formation of pseudomembrane.
c. In severe variety, there may be marked cervical adenitis (bull neck)