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Pharmacology

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Antimicrobial Part-2

Question
6 out of 75
 

Drug causing maximal peripheral neuropathy is:



A Zidovudine
B Lamivudine

C Stavudine
D Didanosine

Ans. C Stavudine

drugs causing peripheral neuropathy are:

a. Cisplatin, Amiodarone, Dapsone, Disulfiram, hydralazine, INH, Metronidazole, Nitrofurantoin, didanosine", zalcitabine, stavudine, phenytoin, pyridoxine, statins, Taxol, vincristine

b. Zidovudine causes myopathy not neuropathy. Hence the confusion is now between stauvdine and didanosine.

c. About didanosine, the most common toxicity is a painful sensory peripheral neuropathy that occurs in -3 0% of patients receiving> 400 mg/dl.

d. About stavudine - Peripheral neuropathy and hepatic steatosis are the main toxicities.

e. Thus, according to us, best answer is didanosine. Some frequently asked questions about antiretroviral drugs:

MC side effect of zidovudine - Myelosuppression. Other side effects of zidovudine are: Fatty liver, myopathy, lactic acidosis, cardio-myopathy. Enzyme inhibited by zidovudine resulting in myo­pathy- DNA polymerase of mitochondria.

Type of anemia seen with zidovudine

Macrocytic anemia nonresponsive to B12 IF A

Pancreatitis causing drugs - Didanosine, Zalcitabine, Stavudine

S/E of Didanosine - Pancreatitis, Painful peri­pheral neuropathy, diarrhea, hepatitis, esophageal ulcer, cardiomyopathy, optic neuritis, steatosis.

RTI active against HBV Lamivudine

Least toxic nucleoside analogue lamivudine

RTI associated with fatal hypersensitivity reaction­ Abacavir "

Side effects of Nevirapine StevenJohnson syndrome, TEN, Hepatotoxicity

S IE of efavirenz - psychiatric (delusion, depression, euphoriA.

Class associated with lipodystrophy - Protease inhibitors

Class associated with risk of spontaneous bleeding­ Protease Inhibitors.

PI with max. CNS penetration - Indinavir

PI with max. drug interaction - Ritonavir.

S/e of Indinavr - Hyperbilirubinemia, Nephro­lithiasis.

Best tolerated PI - Saquinavir.

Antimicrobial Part-2 Flashcard List

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