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Neurology

Question
12 out of 12
 

Drug not used in multiple sclerosis (AIIMS Nov 2011)



A Interferon beta 1a
B Interferon beta 1b

C Glatiramer acetate
D Mycophenolate

Ans. D

Mycophenolate

Treatment of Acute Attack (Ref. Hari-18th ed., pg- 3402)

1). Glucocorticoid treatment - Pulse Methyl Prednisolone

2). Plasma exchange


Prophylaxis Treatment (Disease modifying agent) for relapsing form of MS includes the following drugs–

1). Methotrexate Q

2). Cyclophosphamide

3. Azathioprine


Recent Advances: New Drugs for prophylaxis:


1). Glatiramer acetateQ

2). Mitoxantrone

3). IFN-Beta-1a, 1b

4). Natalizumab

5). Alemtuzumab


Recent Advances in the prophylaxes of MS: (Ref. Hari-18th ed., pg- 3405)

1). Fingolimod is a sphingosine-1-phosphate (S1P) inhibitor and it prevents the egress of lymphocytes from the secondary lymphoid organs such as the lymph nodes and spleen.

2). Cladribine is a purine analog that inhibits DNA synthesis and repair, and acts as a general immunosuppressant.

Extra Edge: Clinical Variants of MS

1. Acute MS (Marburg's variant) is a fulminant demyelinating process that in some cases progresses inexorably to death within 1–2 years. (Ref. Hari- 18th ed., pg- 3408)

2). Neuromyelitis optica (NMO), or Devic's syndrome, is an aggressive inflammatory disorder consisting most typically of attacks of acute ON and myelitis. Attacks of ON can be bilateral (rare in MS) or unilateral; myelitis can be severe and transverse (rare in MS) and is typically longitudinally extensive, involving three or more contiguous vertebral segments. (Ref. Hari- 18th ed., pg- 3407)

Extra Edge : Uses of interferon

1). Interferon alpha

a. Hepatitis B, Hepatitis C

b. Carcinoid syndrome

c. Follicular lymphoma

d. Essential thrombocytosis

e. Mucocutaneous manifestations of Beh|et’s syndrome

f. CML

g. Malignant melanoma

2). Interferon Beta

Multiple sclerosis

3). Interferon γ

a. Osteopetrosis

b. Idiopathic pulmonary fibrosis

c. Chronic granulomatous disease leprosy, non-tuberculosis mycobacteria & visceral leishmaniosis

d. Multiple myeloma

e. Systemic sclerosis

f. Renal cell carcinoma

Neurology Flashcard List

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