Drug of choice for chronic myeloid leukemia is (LQ)
Drugs use in treatment of CML
a. Imatinib mesylate function through competitive inhibition at the adenosine triphosphate ATP binding site of the ABL kinase. It is the drug of choice now days.
b. Interferons—when allogeneic SCT is not feasible IFN alpha therapy used to be the treatment of choice before Imatinib became available.
c. Hydroxyurea—a ribonucleotide reeducates inhibitor induces rapid disease control.
d. Biosulphane—an alkylating agent that acts on early progenitor.