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Physiology

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Nerve Muscle Physiology

Question
16 out of 19
 

Duchenne Muscular dystrophy is a disease of (DNB Pattern)



A Neuromuscular junction

B Sarcolemmal proteins

C Muscle contractile protein

D Disuse atrophy due to muscle weakness

Ans. B Sarcolemmal proteins

a. Duchenne and Becker muscular dystrophies X-linked recessive disorder:

i. Caused by due to production of defective dystrophin or Absence of dystrophin, which is a sarcolemma protein.

Normally, the "dystrophin - glycoprotein complex" appears to confers stability to sarcolemmaQ so, in the cases of these diseases distruption of the dystrophin-glycoprotein complexes weakens the sarcolemma causing membrane tears and a cascade of event leading to muscle fibers necrosis.

b. Diseases due to defect of Neuromuscular junction

i. Myasthenia Gravis Ach Receptor's number are decreased at the post synaptic muscle membrane; anti-Ach R antibodies binds to AchRs, and reduces the available numbers of AchRs. Q

ii. Lambert-Eaton Maasthenia syndrome (LEMS) Presynaptic neuromuscular disorder Q

iii. LMN types paralysis causes Disuse atrophy of muscles weakness (eg. polio). Q

Nerve Muscle Physiology Flashcard List

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