Physiological Changes in Pregnancy
During Ovulation phase :- (AIIMS May 2009)
|A||Increase in inhibin A level|
|B||FSH induce steroidogenesis in granulosa cells|
|D||Stimulation of the arrested meiotic division of the ovum|
a. The activin’s and inhibin‘s are glycoproteins that belong to thetransforming growth factor-beta superfamily.
b. They are secreted from granulose cells.
c. FSH induces steroidogenesis (estradiol production) in granulosa cells in the pre ovulatory phase(follicular phase).
d. Stimulation of the arrested meiotic division of the ovum occurs after fertilization
e. Inhibin B has shows increase levels in mid follicular phase and has a peri ovular peak and then declines in luteal phase.
f. Inhibin A are low in follicular phase ,reaches a small peak in mid follicular phase and increases to reaches a peak in luteal phase.
Activin has biphasic secretion with peak at the time of ovulation and nadir in mid follicular and mid luteal phases.