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Paediatric

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CVS

Question
45 out of 63
 

Ebstein's anomaly is seen with intake of – (AIPG 2011)



A Mercury
B Copper

C Lithium
D Lead

Ans. C

Lithium

o Teratogenic cardiovascular defects of lithium – Ebsteins anomaly, Tricuspid atresia

Etiologv of CHD

i. Ebsteins anomaly, Tricuspid atresi u

ii. The etiology of the majority of C'HDs is not known.

iii. In less than 1096 of cases the cause and effect relationship has been established.

iv. Both environmental and hereditary factors play a role in the etiology of CHDs.

a. Hereditary factors

i. A higher incidence of CHD in siblings suggests heredity as an important factor.

ii. The strongest familial tendency, is known in ASD associated with bony abnormalities (Holt oram syndrome).

iii. Other hereditary conditions have been mentioned in subsequent explanations.

b. Environmental factors

i. Those who have an inherited tendency, develop CHD dut; to unfavorable environmental factors.

ii. Of these the most well-known is high altitude -+ There is higher incidence of PDA and ASD in children born at a high altitude.

iii. Other important environmental factors are: -

Phenytoin

Pulmonary stenosis Aortic stensis

Alcohol

VSD, PDA, ASD, TOF

Rubella

PDA, PS, ASD, VSD

Down’s syndrome

Endocardial cushion defect

ASD, VSD, TOF

Infant of a diabetic

TGA, VSD, COA, PPHN

Cardimoyopathy

Valproate

ASD, VSD, AS, PA, COA

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