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Antidiabetic Drugs                  


Classification
 

  1. Sulfonylureas
     
    Generation-I
    1. Tolbutamide        
    2. Tolazamide          
    3. Acetohexamide    
    4. Chlorpropamide       

Generation-II

  1. Glimepiride          
  2. Glipizide              
  3. Gliclazide              
  4. Glibenclamide 

 

2. Biguniudes

  1. Phenformin          
  2. Metformin 

 

3. Alpha-glucosidase inhibitors

  1. Acarbose              
  2. Gaurgum              
  3. Magilitol       

4. Thiozolidinediones

  1. Trogliatazone                
  2. Rosigliatazone              
  3. Piogliatazone 

 

5. Maglitinides (Secretogens)

  1. Repaglinide          
  2. Nateglinide 

New drugs

  1. Incretin like drugs
(a) GLP 1 analogue
  1. Exenatide
  2. Liraglutide  
(b) Dipeptidyl peptidase inhibitors (DPP IV)
  1. Sitagliaptin  
  2. Ritagliaptin          
  3. Validagliaptin                
  4. Alogliaptin
  1. Amylin analogue
    1. Pramlintide
  2. Aldolase reductase inhibitor
    1. Epalrestat (Used in patients with good glycemic control and limited microangiopathy) 
  3. Renal glucose transporter inhibitors (Sodium Glucose-2 inhibitors)
    1. Phlorozin              
    2. Dapagliflozin        
    3. Sergliflozin            
    4. Remogliflozin   
  4. Bromocriptine(D2) receptor agonist
  5.  Colesevelum (bile acid sequestrant agent)




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