Loading....
Coupon Accepted Successfully!

 

Hypophosphatemia & Hyperphosphatemia

Causes of hypophosphatemia

  1. Reduced renal tubular phosphate reabsorption
    1. PTH/PTHrP -dependent
      1. Hyperparathyroidism                      
      2. PTHrP-dependent hypercalcemia of malignancy
      3. Familial hypocalciuric hypercalcemia
    2. PTH/PTHrP-independent
      1. Genetic hypophosphatemia
        1. X-linked hypophosphatemia rickets
        2. Wilson disease
      2. Other systemic disorders
        1. Poorly controlled diabetes mellitus
        2. Alcoholism
      3. Drugs
        1. Diuretics
        2. Cisplatin
        3. Ifosfamide
        4. Foscarnet
        5. Calcitonin
        6. Pamidronate
  2. Impaired intestinal phosphate absorption
    1. Aluminum-containing antacids
  3. Shifts of extracellular phosphate into cells
    1. Insulin therapy of prolonged hyperglycemia or diabetic ketoacidosis

Causes of Hyperphosphatemia

Decreased renal phosphate excretions

  1. ARF,
  2. CRF,
  3. Hypoparathyroidism,
  4. Pseudo Hypoparathyroidism,
  5. Bisphosphonates,
  6. Acromegaly

Others

  1. Vitamin D intoxication
  2. Acidosis,
  3. Rhabdomyolysis,
  4. Cytotoxic therapy
  5. Tumour lysis Syndrome
  6. Fulminant hepatitis





Test Your Skills Now!
Take a Quiz now
Reviewer Name