Erythromycin is given in intestinal hypomotility:
|A||Because it binds to motilin receptors|
|B||Increases gastric acid secretion|
I. Binds to motilin receptors. Macrolides a group of versatile antibiotics with motilin receptor activating property shared by all the member of the group.
II. That means, it is a class activit. Erythromycin is however most potent and is hence most commonly used for this purpose.
III. Erythromycin is used in diabetic gastroperesis and dyspepsia for its motilin receptor activating activity.
IV. Motilin receptor is a G protein coupled receptor.
V. It is an intestinal peptide that stimulates intestinal contractions.
VI. Since none of the currently available agonists of motilin receptors are ideal drugs. Therefore search for more drugs that could bind to such receptors is on.
VII. Drugs that could bind to motilin could be useful for the treatment of various GI functional motor disorders like gastro-oesophageal reflux disease, gastroparesis, postoperative ileus, scleroderma and idiopathic pseudo-obstruction.