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Biochemistry

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Enzymes

Question
2 out of 20
 

FIGLU is a metabolite of



A Folic acid

B Histidine

C Tyrosine

D Alanine

Ans. B Histidine
  1. FIGLU or N-formimino glutamate is formed during catabolism of Histidine.
  2. During process, transfer of the formimino group of FIGLU to tetrahydrofolate (H folate) forms
  3. glutamate. In folic acid deficiency this reaction is partially or totally blocked, and FIGLU is excreted in the urine.
  4. Excretion of “FIGLU” following a test dose of histidine therefore provides a diagnostic test for folic acid deficiency:
  5. Catabolic path of histidine as: -

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