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Physiology

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Endocrinology

Question
25 out of 50
 

Features of HCG



A Is a glycoprotein

B Has 2 subunits

C Option A,B is right

D Levels increases in third trimester

E Has 2 subunits

Ans. C Is a glycoprotein, Has 2 subunits
  1. HCG ( Human chorionic Gonadotrophin):-

a. HCG is a glycoprotein, mol. wt = 36000 — 40000 daltons

b. Is secreted by the syncytiotrophoblast of the placenta

c. HCG has two subunit: - α and β

    1. (a subunit non specific biochemically and functionally similar to LH, FSH and TSH Q
    2. subunit specific and unique to HCG.

d. By radioimmuno assay it can be detected in the maternal serum or urine as early as 8-9 days following ovulation

e. In the early pregnancy, the doubling, time of HCG conc. in plasma is 1.4 to 2 days.

f. Conc.of HCG in blood and urine: - (During pregnancy)

i. Maximum level (100 IU to 200 IU/ml) at 60-70 days of pregnancy

ii. Slowly falling to 10 to 20 I.U/ml 100-130 days of pregnancy

iii. After that, remains constant with a slight secondary peak at 32 weeks

iv. HCG disappear from the circulation within 2 weeks following delivery

v. HCG-conc: Peak 5 mg/ml during 1st trimester

g. HCG level in

  1. MultiplepregnancyQ
  1. Hydatiform mole Q
  1. Chorio carcinoma Q
  1. Down’s synd: -for downs synd: Triple test →↓ Maternal alpha protein, HCG, and unconjugated- oestriol (E3) Q

  1. Human placental Lactogen or, human chorionic somatomammotropin -

a. Synthesized by syncytiotrophoblast of placenta.

b. Similar to growth hormone and prolactin.

c. Function Increase carbohydrate metabolism it causes mobilization of FFA from maternal fat deposit and shift glucose towards utilization by growing foetus. Due to its anti-insulin effect, protein synthesis is increased as maternal insulin level is high.

d. Values of HPL less than 5g after the 35 weeks indicates the possibility of fetal distress and neonatal asphyxia after delivery.

Endocrinology Flashcard List

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