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Pharmacology

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CNS Part-1

Question
14 out of 58
 

Fetal-hydantoin syndrome is seen in case of (LQ)



A Phenytoin
B Carbamazepine

C Ethosuximide
D Phenobarbitone

Ans. A Phenytoin

a. Dilantin is the brand name of the drug phenytoin sodium, commonly used in the treatment of epilepsy. About one third of children whose mothers are taking this drug during pregnancy develop minor face and limb birth defects.

b. A smaller population will have growth problems and developmental delay, or mental retardation. Heart defects and cleft lip may also be featured.

c. The entire group of defects caused by the drug's teratogenicity is called Fetal Dilantin Syndrome.

d. It may also be called congenital hydantoin syndrome, Fetal Hydantoin Syndrome, Dilantin Embryopathy, or Phenytoin Embryopathy.

e. Fetal alcohol syndrome is the most common differential diagnosis (BG Katzung’ 10th Edition, 2010).

f. It is important to know that there will be both growth and mental deficiency in fetal hydantoin syndrome. Though, the exact mechanism is not known but because folic acid is essential for protein synthesis and growth, and since hydantoin interferes with intestinal transport of folic acid, it has been postulated that part of the fetal hydantoin syndrome may be due to inhibition of placental folic acid by maternal hydantoin.

(Mnemonics: Phenytoin is also know as Diphenylhydantoin, so the teratogenic effect is known as Fetal Hydantoin Syndrome)

CNS Part-1 Flashcard List

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