Final centre for horizontal movements of eye is (AIPG 2009)
1. Subcortical centre for lateral/horizontal conjugate gaze lies in the Pons as PPRF.
2. (Para-median Pontine Reticular Formation).
3. This centre receives input from the contralateral frontal eye field and moves ipsilateral lateral rectus and contralateral medial rectus muscle via projections of MLF (medial longitudinal fasciculus).
4. PPRF lesion leads to inactivity of saccadic movements by lateral rectus and contralateral medial rectus.
5. There is loss of horizontal saccades directed towards the side of the lesion but pursuit and vergence movements are preserved.
6. One and a half syndrome: Unilateral PPRF and unilateral MLF lesion..