Gastrointestinal stromal malignancy arises from which of the following - (AIIMS May 12)
|C||Interstitial cells of Cajal|
a. "Gastrointestinal stromal tumors (GIST) originate from the interstitial cells of Cajal, which control gastrointestinal peristalsis. "
b. On rare occasions, gastric GIST’s occur as part of tumor – syndrome, such as:
i. Carney’s trids → gastric GIST, paraganglioma and pulmonary chondroma.
ii. Neurofibromatosis type I
c. Histologically, GISTs can be divided into
i. Spindle types → exhibit spindle cells
ii. Epitheloid types → exhibit epitheloid cells
iii. Mixed types → A mixture of both