- It is similar to isoflurane except fluorine atom of isoflurane is replaced by chlorine atom which produces significant changes in physical properties.
NOTE: Desflurane irritates air passage leading to cough and laryngospasm because of the pungent odour of its vapours.
- Physical Properties
- It is colourless liquid
- Pungent odour so induction is not pleasant.
- Vapour pressure is very high (681 mm Hg) and boiling point is less than 23oC, so it boils at room temperature that is why a special vaporizer (TEC 6) is required for its delivery.
- Anesthetic Properties
- It is the fastest acting induction agent (B/G coefficient 0.42), potency is medium (MAC is 6%).
- Induction is unpleasant and may at times manifests as coughing, breath holding or laryngospasm.
- Not a good analgesic, relaxation is moderate.
- Systemic Effects:
- Cardiovascular System: Actions are similar to isoflurane except it does not causes coronary steal.
- Respiration: Decreases minute volume and depresses ventilatory responses.
- Cerebral: Increases intracranial tension more than isoflurane.
- Metabolism is least only 0.01%
- Can cause post operative delirium
- Can produce CARBON MONOXIDE with reaction with sodalime