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Pathology

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Immunopathology

Question
5 out of 14
 

HLA antigen locus is on: (AIIMS Nov 2014)



A Long arm of chromosome 6

B Short arm of chromosome 6

C Long arm of chromosome 16

D Short arm chromosome 16

Ans. B Short arm of chromosome 6

Human :Leukocyte Antigen (HLA) System

Located on a portion of chromosome 6. This is called major histocompatibility complex (MHC) or HLA complex.

a. Class I antigens have loci as HLA~A, HLA-B and HLA-C. These antigens are located on all the nucleated cells of the body and platelets.

b. Class II antigens have single locus as HLA-D, These antigens are found on macrophages, B cells and T cells. These have further 3 loci, DR, DQ and DP.

c. Class III antigens are some components of the complements system coded on HLA complex.

Immunopathology Flashcard List

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